Description of the OFSEP sample collection on 8 June 2024

The OFSEP sample collection is composed of biological samples taken in patients from biological cohorts: radiological isolated syndrome (RIS), first attack MS, untreated relapsing-remitting MS (RRMS), untreated primary progressive MS (PPMS), neuromyelitis optica spectrum disorder (NMOSD), myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), acute disseminated encephalomyelitis (ADEM), progressive multifocal leukoencephalopathy (PML) and MS/NMOSD/MOGAD with Covid-19. The RRMS patients, secondary progressive MS (SPMS) and PPMS included in the OFSEP HD cohort are also sampled.

For the biological cohorts, blood samples (serum, plasma, whole blood and peripheral blood mononuclear cells (PBMC)), cerebrospinal fluid and saliva are collected by the participating centers, using OFSEP sampling kits. For the OFSEP HD cohort, only blood tubes are collected.

On 8 June 2024, more than 5,000 patients have been sampled. The derivative biological samples are stored in the 28 OFSEP-participating biobanks.

Patients* N of patients* Blood PBMC CSF Saliva Urine*** Stools*** N patients with iterative samples
RIS 207 207 201 81 47 134 6 32
First attack 1215 1215 829 595 93 683 33 304
RRMS** 2201 2201 302 171 27 220 29 1098
SPMS** 413 413 24 13 2 22 2 183
PPMS** 417 417 277 185 16 224 13 160
PML 10 10 10 2 0 9 0 0
NMOSD 369 369 363 28 56 224 3 56
MOGAD 285 285 279 17 52 168 4 57
ADEM 21 21 21 4 0 15 0 1
Covid-19*** 66 66 65 0 0 21 0 0

* Some patients could be counted several times if they enter an new cohort during the follow-up (ex : RIS => First attack)

** Including patients from the OFSEP High Definition cohort (patients with only blood samples)

*** Closed collection

Blood = serum + EDTA plasma + whole blood for DNA extraction

PBMC = Peripheral blood mononuclear cells

CSF = Cerebrospinal fluid