Description of the OFSEP sample collection on 8 December 2024

The OFSEP sample collection is composed of biological samples taken in patients from biological cohorts: radiological isolated syndrome (RIS), first attack MS, untreated relapsing-remitting MS (RRMS), untreated primary progressive MS (PPMS), neuromyelitis optica spectrum disorder (NMOSD), myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), acute disseminated encephalomyelitis (ADEM), progressive multifocal leukoencephalopathy (PML) and MS/NMOSD/MOGAD with Covid-19. The RRMS patients, secondary progressive MS (SPMS) and PPMS included in the OFSEP HD cohort are also sampled.

For the biological cohorts, blood samples (serum, plasma, whole blood and peripheral blood mononuclear cells (PBMC)), cerebrospinal fluid and saliva are collected by the participating centers, using OFSEP sampling kits. For the OFSEP HD cohort, only blood tubes are collected.

On 8 December 2024, 5,111 patients have been sampled. The derivative biological samples are stored in the 28 OFSEP-participating biobanks.

Patients* N of patients* Blood PBMC CSF Saliva Urine*** Stools*** N patients with iterative samples
RIS 230 230 224 96 68 134 6 35
First attack 1243 1243 853 618 115 681 33 330
RRMS** 2206 2206 303 172 28 219 29 1136
SPMS** 424 424 25 14 3 22 2 202
PPMS** 425 425 285 189 22 225 13 167
PML 10 10 10 2 0 9 0 0
NMOSD 374 374 347 26 62 223 3 62
MOGAD 311 311 306 19 78 168 4 66
ADEM 21 21 21 4 1 15 0 1
Covid-19*** 66 66 65 0 0 21 0 0

* Some patients could be counted several times if they enter an new cohort during the follow-up (ex : RIS => First attack)

** Including patients from the OFSEP High Definition cohort (patients with only blood samples)

*** Closed collection

Blood = serum + EDTA plasma + whole blood for DNA extraction

PBMC = Peripheral blood mononuclear cells

CSF = Cerebrospinal fluid